Prions and Neurodegenerative Disorders

Proteins that act like prions – copies of a normal protein that have been corrupted in ways that cause diseases – might be responsible for disorders that attack the brain and spinal column, according to a new research. Earlier it was thought that only one particular protein could be corrupted in this fashion, but the new research is suggesting that another protein linked to Alzheimer’s disease and many other neurodegenerative conditions also behaves very much like a prion.

According to the research, protein, known as tau, could be corrupted in different ways, and that these different forms of corruption-known as strains-are linked to distinct forms of damage to the brain.

“If we think of these different tau strains as different pathogens, then we can begin to describe many human disorders linked to tau based on the strains that underlie them,” said senior author Diamond, the David Clayson Professor of Neurology. “This may mean that certain antibodies or drugs, for example, will work better against certain disorders than others.”

CJD and Alzheimer's disease transmissible

Prions can be similar to infectious microbes such as bacteria or viruses. Prions are unstoppable and prion disease is fatal.

“When we infected a cell with one of these misshapen copies of tau and allowed the cell to reproduce, the daughter cells contained copies of tau misfolded in the same fashion as the parent cell,” Diamond added in the press release. “Further, if we extracted the tau from an affected cell, we could reintroduce it to a naïve cell, where it would recreate the same aggregate shape. This proves that each of these differently shaped copies of the tau protein can form stable prion strains, like a virus or a bacteria, that can be passed on indefinitely.”

Alzheimer's disease and contagion

Prions are associated with an entire family of neurological disorders that are killing people, wildlife and livestock around the world. These deadly diseases are known as Transmissible Spongiform Encephalopathy (TSE). The operative word is “transmissible.” TSEs include Alzheimer’s disease, Creutzfeldt-Jakob disease, Parkinson’s disease, Huntington’s disease, scrapie, chronic wasting disease and mad cow disease. The disease has killed many species of mammals including dolphins. Victims permanently contaminate the world around them with their bodily fluids. Once contaminated with prions, items cannot be sterilized.

Source: http://www.counselheal.com/articles/9826/20140525/alzheimers-disease-associated-prion-proteins-research-finds.htm

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Gary Chandler is the CEO of Crossbow Communications. He also is the founder of Sacred Seedlings. Chandler also is the author of the Language and Travel Guide To Indonesia. Chandler founded Earth News and is the author of eight books about environmental success stories from around the world. Chandler also is connecting the dots to the global surge in neurological disorders.