Treating Prion Disease With Antibodies

Treatment Cures Alzheimer’s Disease In Mice

A trial of antibody therapy against human prion disease is moving forward, John Collinge, MD, professor of neurology and head of the department of neurodegenerative disease at the University College London Institute of Neurology, reported during his presentation. Dr. Collinge has shown that variant Creutzfeldt-Jakob disease (vCJD) was due to the same strain of prion that caused bovine spongiform encephalopathy, and has been a leader in deepening the understanding of human prion diseases.

Alzheimer's disease prevention

The antibody trial is based on the now well-accepted mechanism of prion propagation by templated misfolding of normal prion protein. The conformation change, from alpha helix to beta sheet, thus creates new seeds that can trigger more misfolding, spreading the infection. Antibodies against the misfolded protein are designed to bind to the misfolded form, sequestering it and preventing it from interacting with normal protein. Because the protein is eventually cleared from the cells, Dr. Collinge said, “if you take the concentration of misfolded protein low enough, you ought to be able to cure the infection.” That has been accomplished in mice, which live into old age rather than die within months. “We can find no prions in them at all. They are effectively cured.”

Those results have laid the groundwork for a first-in-human trial of an antibody, PRN100, in patients with the most aggressive form of vCJD. The initial plan is to give the antibody intravenously, Dr. Collinge said, recognizing that the blood-brain barrier is quite leaky in these patients. If that fails to produce adequate antibody levels in the brain, intraventricular administration is an alternative. Early diagnosis will be critical, Dr. George noted, since the disease course runs so quickly, “but this could be a game-changer for the prion diseases.”

 

Dr. Collinge said that there may be some utility for targeting prions in Alzheimer’s disease, given the evidence that prions may mediate the effect of a-beta on neuronal plasticity. In rats, anti-prion antibody administration can block the deleterious cognitive effects of Alzheimer’s tissue extracts.

Alzheimer's disease epidemic

“There is now real evidence of the potential transmissibility of Alzheimer’s,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

Prion Disease News via http://journals.lww.com/neurotodayonline/Fulltext/2016/05190/News_from_the_AAN_Annual_Meeting__Frontiers_in.7.aspx

public relations firm and public affairs firm Denver and Phoenix

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease and the prion disease epidemic is one of our special areas of practice. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com. Stop prion disease.

The Genesis of A Prion

Prions Are Deadly Proteins

Infectious prions have a trusty accomplice in causing deadly neurological disease, according to research by Geisel biochemist Surachai Supattapone, M.D., Ph.D. Normal, noninfectious prion proteins are usually found in the brain. But when prion proteins misfold, they can become infectious and trigger a number of fatal brain disorders, such as mad cow disease or Creutzfeldt-Jakob disease in humans.

TSEs are caused by a deadly protein called a prion (PREE-on). As such, TSEs also are referred to as prion disease. The critical factor is that prions are unstoppable. The pathogen spreads through the bodily fluids and cell tissue of its victims. All tissue is infectious just because of the contact with the contaminated blood.

TSEs also include Creutzfeldt-Jakob disease, Parkinson’s, Huntington’s, mad cow disease and chronic wasting disease in the deer family. Few, if any, mammals are immune. There is no cure.

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing deadly prions and prion disease. President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. According to Prusiner, TSEs all are on the same disease spectrum, which is more accurately described as prion disease. He claims that all TSEs are caused by prions.

Prions and Prusiner win Nobel Prize

What puzzles scientists is that infectious prions (simply called “prions”), unlike viruses, have no nucleic acids—no DNA or RNA—yet they are able to create distinct, self-propagating strains of prion diseases. Most scientists believe in a protein-only hypothesis in which prions create different strains of disease on their own, and many believe that the hypothesis may apply to other diseases as well, such as Alzheimer’s disease and Parkinson’s disease.

But Supattapone is doubtful. If a prion contains just a single protein, without other essential molecules, “it’s hard to explain why the strains exist first of all,” he says. Another problem with the protein-only hypothesis, he adds, is that “nobody has been able to make infectious prions from just the prion.”

Through a purification process, Supattapone, with Geisel biochemist Nathan Deleault, determined that when a noninfectious prion protein is mixed with a certain phospholipid molecule, named phosphatidylethanolamine (PE), the combination creates an infectious prion. This experiment was the first time anyone had formed infectious prions from only two components (prion protein and PE) and without any nucleic acids.

Read More> http://dartmed.dartmouth.edu/fall12/html/disc_prion/

Copper Promotes Prion Disease

Copper Not The Causative Agent

Many of us are familiar with prion disease as mad cow disease (bovine spongiform encephalopathy) that created a crisis in the global beef industry. Or the strange story of Kuru, a fatal illness affecting a tribe in Papua New Guinea known for cannibalism. Both are forms of prion disease, caused by the abnormal folding of a protein and resulting in progressive neurodegeneration and death. Today, the human form of prion disease is called Creutzfeldt Jakobs Disease (CJD). Even Alzheimer’s disease is now widely considered a prion disease.

While exactly how the protein malfunctions has been shrouded in mystery, scientists at The Scripps Research Institute now report in the journal Proceedings of the National Academy of Sciences (PNAS) that reducing copper in the body delays the onset of disease. Mice lacking a copper-transport gene lived significantly longer when infected with a prion disease than did normal mice.

“This conclusively shows that copper plays a role in the misfolding of the protein, but is not essential to that misfolding,” said Scripps Research Professor Michael Oldstone, who led the new study.

prion disease epidemic

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing deadly prions and prion disease. President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. According to Prusiner, TSEs all are on the same disease spectrum, which is more accurately described as prion disease. He claims that all TSEs are caused by prions.

Prions are unstoppable and the pathogen spreads through the bodily fluids and cell tissue of its victims. Prions shed from humans are the most deadly mutation. They demand more respect than radiation. Infected surgical instruments, for example, are impossible to sterilize and hospitals throw them away. Prions are in the blood, saliva, urine, feces, mucus, and bodily tissue of its victims.

Many factors are contributing to the epidemic. Prions are now the X factor. Industry and government are not accounting for them or regulating them. They are ignoring the threat completely, which violates the Bioterrorism Preparedness and Response Act of 2002 in the United States. Other nations also are ignoring laws developed to protect food, air and water.

Alzheimer's disease epidemic

“There is now real evidence of the potential transmissibility of Alzheimer’s disease,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

A new study published in the journal Nature renews concern about the transmissibility of Alzheimer’s disease between people. A second study by the same scientist in early 2016 adds to the stack of evidence.

http://www.healthcanal.com/brain-nerves/31489-Scripps-Research-Institute-Scientists-Show-Copper-Facilitates-Prion-Disease.html

public relations firm and public affairs firm Denver and Phoenix

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Mad Cow Disease Related To Alzheimer’s Disease

Prions Link Mad Cow Disease, Chronic Wasting Disease and Alzheimer’s Disease

Prion disease is being mismanaged around the globe, which is contributing to the migration, mutation, and exponential growth in the deadly contagion. Our food, water and healthcare systems are now critical pathways that must be guarded much more closely.

Not surprisingly, mad cow disease, clinically known as bovine spongiform encephalopathy (BSE), has been rampant in the U.S. for decades. The human form of mad cow is Creutzfeldt-Jakob disease (CJD). The USDA and FDA have done a very good job of keeping this under wraps, as well as displaying a healthy disregard for human life by their neglect as well as their silence. The testing on cattle raised for food in the U.S. is ‘careless’ and ‘irresponsible’ according to The World Health Organization (WHO). The mismanagement goes much further than mad cow disease.

mad cow disease and prions

Testing one cow out of every 2,000 animals slaughtered is reckless, since the disease is unstoppable in soil, water and other areas infected by victims. Because of this fact, no one knows how many infected cattle enter the human food chain; however it is certain it leads to CJD and Alzheimer’s disease.

Food Safety and WHO Precautions

WHO has issued a warning stating that the U.S. is violating the guidelines set forth for the prevention of BSE or mad cow disease making its way into the human population. WHO states that the U.S. is inadequately testing the brains of human dementia victims and is likely missing hundreds of human cases of Creutzfeldt Jakob Disease (CJD), caused by the reckless management of prion pathways, including human sewage, sewage sludge and biosolids.

The warning goes on to state that the feeding of infected animals to other animals must be ceased immediately. The feeding of slaughterhouse waste (which also goes into the sewage systems around the world), including blood, feathers and excrement, to other farmed animals is causing major health risks to all who eat beef, or any other farmed animal. Deer, elk, sheep, pigs and chickens can all carry this disease in different forms.

Prions and Prusiner win Nobel Prize

Prions Connect Alzheimer’s CJD and Mad Cow Disease

CJD and Alzheimer’s disease are caused by an infectious prion, which is (not) a virus. A prion is a protein, but a mutated protein that is somewhat different in shape. These prions fold into an abnormal pattern, at which time they begin killing off brain cells by the millions.

Steven Strittmatter, Professor of Neurology at Yale University, comments, “It’s too bizarre that these two diseases would share this common protein.”

Further, a well-known physician said, “The most frequent misdiagnosis of CJD among the elderly is Alzheimer’s disease. Neither CJD nor Alzheimer’s can be conclusively diagnosed without a brain biopsy, and the symptoms and pathology of both diseases overlap,” said Michael Greger, M.D.

The gestation period for this prion can be years or even decades. The problem with this is that many people infected will not even show signs of the disease for years, and the final death toll may not show up until it’s too late to actually do something about the rest of the population. Also, since CJD is often mis-diagnosed, getting the true picture will be difficult.

Regrettably, the National Institute of Neurological Disorders indicates that there is not one single diagnostic test for detecting CJD. The only way to confirm a diagnosis of CJD is by brain biopsy or autopsy. The biopsy is a dangerous procedure because it means removing a part of a person’s brain, and getting the part that is infected is not likely. And, when testing in either autopsy or biopsy, surgeons performing the test have to take extreme care to be certain they don’t become infected themselves. Strict surgical and disinfection procedures must be followed to perform this kind of test.

I’d venture to say that most doctors would do just about anything BUT this, in order to avoid the risks involved, as well as the time and expense; hence – misdiagnosis.

Alzheimer's disease epidemic

Alzheimer’s Disease Epidemic

Today, Alzheimer’s disease is the 6th leading cause of death in the U.S. It is the only disease that causes certain death, because it cannot be prevented by medicine, or cured or even slowed down.

From 2000 to 2008, in the U.S. alone, deaths from Alzheimer’s disease have risen sixty-six percent (66%). An estimated 5.4 million people in the U.S. have Alzheimer’s in 2011.  This includes people over the age of 65, and younger people who have young-onset Alzheimer’s.

Scientists believe it is Mad Cow gone rampant and have found a possible link to this horrible brain-wasting disease – and most other types of dementia. A link to Parkinson’s, Huntington’s disease, Lou Gehrig’s disease, and others has also been made.

Dr. Greger explains, “Mad-Cow disease is caused by unconventional pathogens called prions–literally infectious proteins–which, because of their unique structure, are practically invulnerable, surviving even incineration at temperatures hot enough to melt lead.”   Sadly, pigs can also carry the disease and since they are slaughtered long before any symptoms can surface, it is difficult to diagnose.

land application sewage sludge

According to Dr. Greger: “Laboratory experiments show that pigs can indeed be infected by Mad-Cow brains– and hundreds of thousands of downer pigs, too sick or crippled by injury to even walk, arrive at U.S. slaughterhouses every year.”

Read More> http://www.opednews.com/articles/Prevent-Alzheimer-s-Diseas-by-Tina-Volpe-121222-380.html

public relations firm and public affairs firm Denver and Phoenix

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.