Prions Not Stopped By Species Barriers

Prion Disease Killing Many Mammals

Prions are known to migrate, mutate and multiply. They become more voracious as they move from one host to another. New research adds to the bank of evidence that a deadly prion is a deadly prion and they know no borders between species. For years, food safety experts and wildlife managers have put people at ease by hiding behind the myth of species barriers. Blind faith can kill you when it comes to prion dynamics.

Canadian researchers recently discovered a slight change in prions’ makeup appears to give mad cow disease the ability to adapt and spread to other animals. Mutation still is likely a more accurate term, but “adaptation” is close enough for government work. I think the “adaptation” is the equivalent of a chemical reaction that takes place when prions are exposed to a new bank of proteins in a new host (victim).

prion disease epidemic

Neurologist Valerie Sim and her research team at the University of Alberta said the findings might explain how prion diseases, such as chronic wasting disease and mad cow disease, adapt in order to spread between various types of animals.

The prions’ makeup appears to give the disease the ability to adapt by mimicking and recreating new strains with which it comes into contact.

“Prion diseases don’t always successfully go from one animal to another, but when they do, the process is called adaptation. And we want to figure out what triggers that process to happen, what changes happen within prions to allow the disease to spread,” Sim said in a statement.

land application sewage sludge

“One of the important things researchers in this field have realized is that if you pass certain strains of prion disease through a number of different hosts, the disease can adapt along the way and increase the number of susceptible hosts. That’s the big concern right now.”

The findings were published in the Journal of Biological Chemistry.

Prions are associated with an entire family of neurological disorders that are killing people, wildlife and livestock around the world. These diseases are known as transmissible spongiform encephalopathy (TSE). The operative word is “transmissible.” TSEs include Alzheimer’s disease, Creutzfeldt-Jakob disease, Parkinson’s disease, Huntington’s disease, scrapie, chronic wasting disease and mad cow disease. The disease has killed many species of mammals including dolphins and likely is killing whales.

chronic wasting disease caused by prions

Read more: http://www.upi.com/Health_News/2013/03/17/Mad-cow-disease-adaptation-key-found/UPI-34591363498413/#ixzz2Np9pCJ6h

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Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Criminal Puts Bad Beef Into Food Supply

The following case demonstrates how farmers are willing and able to ignore food safety laws around the world, while regulators have little leverage over the situation and the judicial system slaps them on the wrist for taking deadly risks with the health of millions of people. Prion mismanagement is a serious threat to life as we know it.

Another Case Of Prion Mismanagement

Carlisle Crown Court heard that the crimes committed by David Holmes, 52, led to the disappearance of 33 cattle. They likely became hamburgers and pot roast for unsuspecting families across the UK and could have contaminated the entire production chain.

mad cow disease and prions

Many of the cows were born before 1996, meaning that they posed a potential risk to humans if they ever got into the food chain. Infected meat has been blamed for causing most of the 170 deaths in the UK from the brain disease variant CJD, the human form of BSE, also known as mad cow disease.

Some of Holmes’ animals were at Crook Farm, Roadhead, north of Carlisle.

Passing sentence, Judge Peter Davies told the farmer: “I am satisfied that these offenses were committed deliberately for commercial profit.” The judge said that it was imperative that diseased cattle were not provided for human consumption.

Holmes flouted the regulations, deliberately obstructing the authorities and failing to keep proper records.

As a result, 33 of the defendant’s cattle could not be traced, having been sold “at great risk to the public”, said Judge Davies, who added: “It was a cynical pattern of offending, without consideration for the public.”

The court heard there was no evidence that any infected meat had actually entered the human food chain.

At an earlier hearing, Holmes, now living at Nutholm Farm, Lockerbie, admitted 30 counts of contravening cattle identification and movement regulations. He repeatedly failed to notify the British Cattle Movement Service (BCMS) that he was moving cattle between different locations.

The offences included failing to keep a proper register of his herds, using an ear tag on a cow previously that identified another animal, and giving officials misleading information about his cows.

The crimes were committed on a continuous basis between 2009 and 2011. They happened at the farm near Carlisle, and at others in Northumberland, Staffordshire, and Derbyshire.

Holmes has previous convictions which date back to the 1980s, including a number of animal cruelty offenses.

The farmer’s barrister pointed out he had given up cattle dealing, and the company he ran for that purpose – D&A Livestock Limited – was in liquidation and would not be resurrected.

The judge said figures showed the defendant’s business generated just short of £143,000 in the last nine months, while his remaining cattle are valued at between £30,000 and £45,000, so there was no reason for Holmes not to pay costs.

The judge imposed a fine of £3,000 and prosecution costs of £6,600. Holmes will have to serve three months in jail if he fails to pay up.

In addition he was given a 12-month jail term, suspended for two years, and told to do 150 hours of unpaid work in the community.

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Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

 

Another Case Of Mad Cow Disease In U.S.

Mad Cow Disease Exposes Prion Mismanagement

The random testing system for BSE (mad cow disease) caught another dairy cow last year in Central California. The good news is that the meat was kept from the food supply. The question is whether or not humans consumed her milk? Or that of other animals that never exhibited clinical signs of the disease, but were carriers of deadly prions–as officials claim happened in Brazil recently.

mad cow disease

What also isn’t addressed is the fact that prions have been found in the saliva of cattle. We must assume that prions are in urine, feces, blood and milk at the very least. Therefore, how much land, water, equipment and livestock does a prion carrier contaminate among the path to its demise? Why did they reopen the dairy where the cow with BSE came from?

The soil, pens, water tanks, and milk stalls were all likely exposed to prions, which can’t be sterilized. Why are we still marketing beef tongue? Why do we allow untested livestock to roam public lands, where they can expose wildlife to prions and visa versa. Why do we render untested animals and use the byproducts in pet food, lotions, gel caps and other products that are potential prion pathways? Why are we sending hunters into CWD zones to kill and consume sick deer, elk, and moose? Are they informed of the prion dangers to their homes and families when animals subsequently test positive (weeks later if tested at all)? Why are we killing wolves in states such as Wisconsin, Wyoming and Minnesota and others that have chronic wasting disease among wildlife? Wolves can help limit the spread of deadly prions by taking down sick animals as soon as they become weakened by the disease.

What are we doing to protect our blood supplies and dental equipment? Shouldn’t we start treating Alzheimer’s disease like a prion disease and put up the appropriate safeguards in our homes, hospital and communities?

Alzheimer's disease prevention

Given the amount of people with Alzheimer’s disease and Creutzfeldt-Jakob disease (CJD), we undoubtedly have contaminated our sewage systems with deadly prions (again, prions are in urine, feces, blood, milk and other bodily fluids–ask a surgeon or a coroner). Therefore, why are we recycling waste water and disease via water and biosolids? Prions cannot be neutralized or removed from sewage. Spreading them on golf courses, parks and crops is not a great idea.

land application sewage sludge

The prion peril is real. We can’t afford to mismanage this issue or misinform stakeholders.  Unlike radiation, prions do not have a half life. They grow exponentially and they seem to mutate along the way. There is not a cure for prion disease in any species. Since so much is still unknown, we must assume that all mammals are ravaged by prions in a similar manner. Therefore, we can’t afford to duplicate studies among all species before we alter policies, procedures and overall safeguards accordingly for the sake of better prion management and containment. It’s better to error on the safe side of prion management, if we are to error at all. The following video is an interesting punctuation point.

http://www.examiner.com/video/u-s-finds-first-case-of-mad-cow-disease-six-years

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Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Britain Doubles Estimate Of People Carrying Prion Pathogen

Mad Cow Disease A Symptom Of Bigger Problems

About 24,000 people in the UK are carrying the agent that can cause the deadly brain condition Creutzfeldt Jakob disease (CJD), linked with eating infected meat – twice the number previously estimated by scientists. The latest figure is based on a study of 30,000 appendixes removed in operations which were tested for the presence of the prion, or misfolded protein, that causes the condition.

mad cow disease and prions

More than a decade ago ministers assured the public that beef was safe to eat, and then had to eat their words when, in March 1996, it was announced that a new disease, variant CJD, had been discovered in humans.

It had come from eating meat from cows infected with bovine spongiform encephalopathy (BSE), a similar disease caused by the now discontinued practice of feeding ground-up animal carcasses to cows as part of their diet. BSE became known as mad cow disease, and in humans CJD is characterized by rapidly progressive dementia and death.

However, only a small proportion of people who carried the prion developed the clinical disease. There have been 173 cases of variant CJD in the UK since it was first identified in 1996.

prion disease epidemic

The number of carriers of the prion is significant because there is a theoretical risk they could spread the disease through blood transfusions or surgical instruments which are not properly sterilized between operations.

Tough measures are in place to minimize these risks. The Health Protection Agency, which published the new figures, said one in 2,000 of the adult population of Britain were carriers of the condition, compared with one in 4,000 shown in a smaller survey in 2004.

Older people, born before 1961, were twice as likely to be carriers as younger people, yet less likely to develop the disease. Professor Sheila Bird of the Medical Research Council Biostatistics unit in Cambridge said: “Our dietary studies suggested older people were more exposed [to BSE infected meat] but they weren’t turning up as clinical cases. They appear to be protected in some way. This shows how important it is to do the surveillance.”

Professor Hugh Perry, chair of the MRC’s neuroscience and mental health board, said: “These figures reinforce the importance that our efforts to prevent, diagnose and treat this devastating disease progress as rigorously as possible.”

A Department of Health spokesman said: “These findings relate to people’s potential to develop vCJD, not additional cases – in fact there have been no new UK cases for nearly two years.

“We have one of the safest blood supplies in the world, but experts will consider the Health Protection Agency study, and any additional measures to reduce the potential risk of transmission through blood transfusions will be put into place.”

The spokesman denied that a delay in publication of the findings was an attempt to bury bad news during the Olympics. “This was a technical study and part of the regular Health Protection Report that is always released on a Friday afternoon,” he said.

“There is now real evidence of the potential transmissibility of Alzheimer’s disease,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

http://www.independent.co.uk/life-style/health-and-families/health-news/up-to-one-in-2000-britons-could-carry-cjd-agent-8031920.html

public relations firm and public affairs firm Denver and Phoenix

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Copper Promotes Prion Disease

Copper Not The Causative Agent

Many of us are familiar with prion disease as mad cow disease (bovine spongiform encephalopathy) that created a crisis in the global beef industry. Or the strange story of Kuru, a fatal illness affecting a tribe in Papua New Guinea known for cannibalism. Both are forms of prion disease, caused by the abnormal folding of a protein and resulting in progressive neurodegeneration and death. Today, the human form of prion disease is called Creutzfeldt Jakobs Disease (CJD). Even Alzheimer’s disease is now widely considered a prion disease.

While exactly how the protein malfunctions has been shrouded in mystery, scientists at The Scripps Research Institute now report in the journal Proceedings of the National Academy of Sciences (PNAS) that reducing copper in the body delays the onset of disease. Mice lacking a copper-transport gene lived significantly longer when infected with a prion disease than did normal mice.

“This conclusively shows that copper plays a role in the misfolding of the protein, but is not essential to that misfolding,” said Scripps Research Professor Michael Oldstone, who led the new study.

prion disease epidemic

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing deadly prions and prion disease. President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. According to Prusiner, TSEs all are on the same disease spectrum, which is more accurately described as prion disease. He claims that all TSEs are caused by prions.

Prions are unstoppable and the pathogen spreads through the bodily fluids and cell tissue of its victims. Prions shed from humans are the most deadly mutation. They demand more respect than radiation. Infected surgical instruments, for example, are impossible to sterilize and hospitals throw them away. Prions are in the blood, saliva, urine, feces, mucus, and bodily tissue of its victims.

Many factors are contributing to the epidemic. Prions are now the X factor. Industry and government are not accounting for them or regulating them. They are ignoring the threat completely, which violates the Bioterrorism Preparedness and Response Act of 2002 in the United States. Other nations also are ignoring laws developed to protect food, air and water.

Alzheimer's disease epidemic

“There is now real evidence of the potential transmissibility of Alzheimer’s disease,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

A new study published in the journal Nature renews concern about the transmissibility of Alzheimer’s disease between people. A second study by the same scientist in early 2016 adds to the stack of evidence.

http://www.healthcanal.com/brain-nerves/31489-Scripps-Research-Institute-Scientists-Show-Copper-Facilitates-Prion-Disease.html

public relations firm and public affairs firm Denver and Phoenix

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Florida Woman Dies Of Creutzfeldt-Jakob Disease

CJD Takes Florida Woman

Charlie Bryant is choosing to remember his mother how he saw her most of his life. “She was just the most incredible, charismatic woman,” Bryant said. At 58-years-old, Stephanie Bryant was diagnosed with Creutzfeldt-Jakob Disease (CJD), also known as the human form of mad cow disease–a prion disease. Within months, Stephanie’s health quickly deteriorated. She suffered from memory loss, constant tremors, couldn’t walk and barely talk. Stephanie Bryant passed away Wednesday, Aug. 1.

“It’s the sickest, meanest disease,” Charlie Bryant said.

Prions are unstoppable and the pathogen spreads through the bodily fluids and cell tissue of its victims. Prions shed from humans are the most deadly mutation. They demand more respect than radiation. Infected surgical instruments, for example, are impossible to sterilize and hospitals throw them away. Prions are in the blood, saliva, urine, feces, mucus, and bodily tissue of its victims.

Many factors are contributing to the epidemic. Prions are now the X factor. Industry and government are not accounting for them or regulating them. They are ignoring the threat completely, which violates the Bioterrorism Preparedness and Response Act of 2002 in the United States. Other nations also are ignoring laws developed to protect food, air and water.

prion disease epidemic

“There is now real evidence of the potential transmissibility of Alzheimer’s disease,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

A new study published in the journal Nature renews concern about the transmissibility of Alzheimer’s disease between people. A second study by the same scientist in early 2016 adds to the stack of evidence.

http://www.abc-7.com/story/19198888/woman-with-mad-cow-disease-passes-away

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Creutzfeldt-Jakob Disease In Greenville Hospital System

CJD Exposure In U.S. Hospital

Eleven people who underwent brain surgery at a South Carolina hospital earlier this year  may have been exposed to a deadly neurodegenerative disorder called Creutzfeldt-Jakob disease (CJD).

Prions and Prusiner win Nobel Prize

Reuters reported that a brain surgery patient in February at Greenville Hospital System was later found to have the extremely fatal brain disease. However, before this discovery was made, the same surgical tools were used on 11 other brain surgery patients, though the tools had been sterilized. Unfortunately, protocol typically calls for disposal, not reuse, of all surgical tools used on patients with prion disease.

Prions are unstoppable and the pathogen spreads through the bodily fluids and cell tissue of its victims. Prions shed from humans are the most deadly mutation. They demand more respect than radiation. Infected surgical instruments, for example, are impossible to sterilize and hospitals throw them away. Prions are in the blood, saliva, urine, feces, mucus, and bodily tissue of its victims. Many factors are contributing to the epidemic. Prions are now the X factor. Industry and government are not accounting for them or regulating them. They are ignoring the threat completely, which violates the Bioterrorism Preparedness and Response Act of 2002 in the United States. Other nations also are ignoring laws developed to protect food, air and water.

“There is now real evidence of the potential transmissibility of Alzheimer’s disease,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

A new study published in the journal Nature renews concern about the transmissibility of Alzheimer’s disease between people. A second study by the same scientist in early 2016 adds to the stack of evidence.

Prion disease is always fatal–there is not a known cure and there is not a known way to neutralize them 100 percent. As such, prions are known to migrate, mutate, multiply and kill people, livestock and wildlife.

http://www.huffingtonpost.com/2012/07/31/creutzfeldt-jakob-disease-exposure-greenville-hospital-system_n_1725942.html

public relations firm and public affairs firm Denver and Phoenix

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Brain Disease Recycled Through Sewage Sludge

Biosolids Spreading Brain Disease

Colm Kelleher, the author of Brain Trust: The Hidden Connection Between Mad Cow Disease and Alzheimer’s Disease is a fascinating book that covers al lot of ground quickly. It connects many dots about deadly prion diseases.

One pathway that he doesn’t mention is sewage sludge, which exposes livestock, wildlife and humans to the largest prion pathway in the world. Beef and dairy cattle are raised on land contaminated with infectious waste. The infectious prions also contaminate water supplies from that point to downstream reservoirs, including creeks, ponds, rivers, lakes and oceans.

land application sewage sludge

If you study the rates of AD and its geographical distribution, you will find that rates start to soar when a country becomes meat eating (i.e. Japan and Korea in the 1960s) and rises even faster when it adopts a fast food culture (the US and Western Europe in the 50s and 60s) and remains low in vegetarian countries (India) and those without a processed meat industry or fast foods (equatorial Africa)…Murray “

 

Rendering plants, which yearly process over 1 million downer cows  – the ones most likely
to have with prion disease –  can result in infected feeds. Industrial meat packing vats of hamburger, each containing meat from 50 to 100 animals from multiple states and two to four countries may also promote contamination and infection.

In order to understand the threat, one must understand the dynamics of this neurological disease. Alzheimer’s disease, for example, is a member of an aggressive family of neurodegenerative diseases known as Transmissible Spongiform Encephalopathy (TSE). The operative word is “transmissible.”

TSEs are caused by a deadly protein called a prion (PREE-on). As such, TSEs also are referred to as prion disease. The critical factor is that prions are unstoppable. The pathogen spreads through the bodily fluids and cell tissue of its victims. Blood, saliva, mucus, milk, urine and feces carry deadly prions from victims. All tissue is infectious just because of the contact with the contaminated blood.

TSEs also include Creutzfeldt-Jakob disease, Parkinson’s, Huntington’s, mad cow disease and chronic wasting disease in the deer family. Few, if any, mammals are immune. There is no cure.

prion disease epidemic

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing deadly prions and prion disease. President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. According to Prusiner, TSEs all are on the same disease spectrum, which is more accurately described as prion disease. He claims that all TSEs are caused by prions.

Prions are unstoppable and the pathogen spreads through the bodily fluids and cell tissue of its victims. Prions shed from humans are the most deadly mutation. They demand more respect than radiation. Infected surgical instruments, for example, are impossible to sterilize and hospitals throw them away. Prions are in the blood, saliva, urine, feces, mucus, and bodily tissue of its victims. Many factors are contributing to the epidemic. Prions are now the X factor. Industry and government are not accounting for them or regulating them. They are ignoring the threat completely, which violates the Bioterrorism Preparedness and Response Act of 2002 in the United States. Other nations also are ignoring laws developed to protect food, air and water.

“There is now real evidence of the potential transmissibility of Alzheimer’s disease,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

A new study published in the journal Nature renews concern about the transmissibility of Alzheimer’s disease between people. A second study by the same scientist in early 2016 adds to the stack of evidence.

mad cow disease and prions

It’s highly probable that livestock and wildlife are contracting TSEs from humans via sewage sludge, also known as biosolids. Consuming milk and meat from infected animals brings the disease back into the human food chain. In other words, we’re recycling Alzheimer’s disease and Creutzfeldt-Jakob disease becasue of the mismanagement of infectious waste.

public relations firm USA

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.