Researchers Study Prion’s Role In Alzheimer’s Disease

Prions Behind Most Neurodegenerative Disorders

Proteins that act like prions – copies of a normal protein that have been corrupted in ways that cause diseases – might be responsible for disorders that attack the brain and spinal column, according to a new research. Earlier it was thought that only one particular protein could be corrupted in this fashion, but the new research is suggesting that another protein linked to Alzheimer’s disease and many other neurodegenerative conditions also behaves very much like a prion.

According to the research, protein, known as tau, could be corrupted in different ways, and that these different forms of corruption-known as strains-are linked to distinct forms of damage to the brain.

Alzheimer's disease epidemic

“If we think of these different tau strains as different pathogens, then we can begin to describe many human disorders linked to tau based on the strains that underlie them,” said senior author Diamond, the David Clayson Professor of Neurology, in the press release. “This may mean that certain antibodies or drugs, for example, will work better against certain disorders than others.”

Prions are made of normal proteins that have folded into an abnormal shape but aren’t alive. However their effects can be similar to infectious microbes such as bacteria or viruses. Prions are unstoppable and prion disease is fatal.

“When we infected a cell with one of these misshapen copies of tau and allowed the cell to reproduce, the daughter cells contained copies of tau misfolded in the same fashion as the parent cell,” Diamond added in the press release. “Further, if we extracted the tau from an affected cell, we could reintroduce it to a naïve cell, where it would recreate the same aggregate shape. This proves that each of these differently shaped copies of the tau protein can form stable prion strains, like a virus or a bacteria, that can be passed on indefinitely.”

Researchers said they are now working to find a way to isolate tau prions non-invasively from individuals for diagnostic purposes. The findings of the study will be published in Neuron.

prion disease epidemic

Prions are associated with an entire family of neurological disorders that are killing people, wildlife and livestock around the world. These deadly diseases are known as Transmissible Spongiform Encephalopathy (TSE). The operative word is “transmissible.” TSEs include Alzheimer’s disease, Creutzfeldt-Jakob disease, Parkinson’s disease, Huntington’s disease, scrapie, chronic wasting disease and mad cow disease. The disease has killed many species of mammals including dolphins. Victims permanently contaminate the world around them with their bodily fluids. Once contaminated with prions, items cannot be sterilized.

Source: http://www.counselheal.com/articles/9826/20140525/alzheimers-disease-associated-prion-proteins-research-finds.htm

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Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Alzheimer’s Epidemic Spreading In All Countries

Caregivers At Risk Of Infection From Alzheimer’s Disease Patients 

Approximately 40 million people around the world already have Alzheimer’s disease and the numbers are rising rapidly. Since the disease barely existed a century ago, Alzheimer’s disease and several related diseases fit the definition of a global epidemic.

My new book explains why Alzheimer’s disease is contagious in many, if not all, cases. It explores why some regions of the world have death rates that are off the charts. It breaks down the causes and offers advice to protect you and your family.

Alzheimer's disease epidemic

Alzheimer’s deaths in the U.S. alone increased 68 percent between 2000 and 2010. During that same time, deaths from other major diseases, including heart disease and cancer, decreased significantly. Most developed countries are making progress on all health fronts, except for Alzheimer’s and other forms of dementia.

This book explores Alzheimer’s disease as part of a protein epidemic. It makes several critical points and asks some challenging questions about a form of killer protein known as a “prion” (pronounced PREE-on).

Deadly prions are contagious and unstoppable. They are definitely behind some forms of neurodegenerative disorders in mammals, including humans. A Nobel-Prize-winning scientist claims that Alzheimer’s, Parkinson’s and Huntington’s diseases all are prion diseases. In addition, prions are behind a deadly epidemic among deer, elk and moose in North America and South Korea called Chronic Wasting disease (CWD).

CWD, like Alzheimer’s, is a neurodegenerative disorder that consumes the brain. Thousands of animals have died and are still dying of the disease, while spreading the deadly infection before and after death.

In my opinion, since we have a global prion epidemic among people and regional ones among wildlife, it stands to reason that livestock also are impacted. Unfortunately, we don’t comprehensively test our food supply for prions, so we don’t know to what extent prion disease is, or isn’t, in global herds that supply meat, dairy, and other products. As we discuss later, these deadly proteins have likely made it into our water supplies, too. In some cases, we are even releasing them into the air.

Prions are associated with an entire family of neurological disorders that are killing people, wildlife and livestock around the world. These deadly diseases are known as Transmissible Spongiform Encephalopathy (TSE). The operative word is “transmissible.” TSEs include Alzheimer’s disease, Creutzfeldt-Jakob disease, Parkinson’s disease, Huntington’s disease, scrapie, chronic wasting disease and mad cow disease. The disease has killed many species of mammals including dolphins. Victims permanently contaminate the world around them with their bodily fluids. Once contaminated with prions, items cannot be sterilized.

For more information or to buy the E-book, please visit http://alzheimerdisease.tv/alzheimers-disease-epidemic/

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Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Prions Not Stopped By Species Barriers

Prion Disease Killing Many Mammals

Prions are known to migrate, mutate and multiply. They become more voracious as they move from one host to another. New research adds to the bank of evidence that a deadly prion is a deadly prion and they know no borders between species. For years, food safety experts and wildlife managers have put people at ease by hiding behind the myth of species barriers. Blind faith can kill you when it comes to prion dynamics.

Canadian researchers recently discovered a slight change in prions’ makeup appears to give mad cow disease the ability to adapt and spread to other animals. Mutation still is likely a more accurate term, but “adaptation” is close enough for government work. I think the “adaptation” is the equivalent of a chemical reaction that takes place when prions are exposed to a new bank of proteins in a new host (victim).

prion disease epidemic

Neurologist Valerie Sim and her research team at the University of Alberta said the findings might explain how prion diseases, such as chronic wasting disease and mad cow disease, adapt in order to spread between various types of animals.

The prions’ makeup appears to give the disease the ability to adapt by mimicking and recreating new strains with which it comes into contact.

“Prion diseases don’t always successfully go from one animal to another, but when they do, the process is called adaptation. And we want to figure out what triggers that process to happen, what changes happen within prions to allow the disease to spread,” Sim said in a statement.

land application sewage sludge

“One of the important things researchers in this field have realized is that if you pass certain strains of prion disease through a number of different hosts, the disease can adapt along the way and increase the number of susceptible hosts. That’s the big concern right now.”

The findings were published in the Journal of Biological Chemistry.

Prions are associated with an entire family of neurological disorders that are killing people, wildlife and livestock around the world. These diseases are known as transmissible spongiform encephalopathy (TSE). The operative word is “transmissible.” TSEs include Alzheimer’s disease, Creutzfeldt-Jakob disease, Parkinson’s disease, Huntington’s disease, scrapie, chronic wasting disease and mad cow disease. The disease has killed many species of mammals including dolphins and likely is killing whales.

chronic wasting disease caused by prions

Read more: http://www.upi.com/Health_News/2013/03/17/Mad-cow-disease-adaptation-key-found/UPI-34591363498413/#ixzz2Np9pCJ6h

public relations firm and public affairs firm Denver and Phoenix

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Another Case Of Mad Cow Disease In U.S.

Mad Cow Disease Exposes Prion Mismanagement

The random testing system for BSE (mad cow disease) caught another dairy cow last year in Central California. The good news is that the meat was kept from the food supply. The question is whether or not humans consumed her milk? Or that of other animals that never exhibited clinical signs of the disease, but were carriers of deadly prions–as officials claim happened in Brazil recently.

mad cow disease

What also isn’t addressed is the fact that prions have been found in the saliva of cattle. We must assume that prions are in urine, feces, blood and milk at the very least. Therefore, how much land, water, equipment and livestock does a prion carrier contaminate among the path to its demise? Why did they reopen the dairy where the cow with BSE came from?

The soil, pens, water tanks, and milk stalls were all likely exposed to prions, which can’t be sterilized. Why are we still marketing beef tongue? Why do we allow untested livestock to roam public lands, where they can expose wildlife to prions and visa versa. Why do we render untested animals and use the byproducts in pet food, lotions, gel caps and other products that are potential prion pathways? Why are we sending hunters into CWD zones to kill and consume sick deer, elk, and moose? Are they informed of the prion dangers to their homes and families when animals subsequently test positive (weeks later if tested at all)? Why are we killing wolves in states such as Wisconsin, Wyoming and Minnesota and others that have chronic wasting disease among wildlife? Wolves can help limit the spread of deadly prions by taking down sick animals as soon as they become weakened by the disease.

What are we doing to protect our blood supplies and dental equipment? Shouldn’t we start treating Alzheimer’s disease like a prion disease and put up the appropriate safeguards in our homes, hospital and communities?

Alzheimer's disease prevention

Given the amount of people with Alzheimer’s disease and Creutzfeldt-Jakob disease (CJD), we undoubtedly have contaminated our sewage systems with deadly prions (again, prions are in urine, feces, blood, milk and other bodily fluids–ask a surgeon or a coroner). Therefore, why are we recycling waste water and disease via water and biosolids? Prions cannot be neutralized or removed from sewage. Spreading them on golf courses, parks and crops is not a great idea.

land application sewage sludge

The prion peril is real. We can’t afford to mismanage this issue or misinform stakeholders.  Unlike radiation, prions do not have a half life. They grow exponentially and they seem to mutate along the way. There is not a cure for prion disease in any species. Since so much is still unknown, we must assume that all mammals are ravaged by prions in a similar manner. Therefore, we can’t afford to duplicate studies among all species before we alter policies, procedures and overall safeguards accordingly for the sake of better prion management and containment. It’s better to error on the safe side of prion management, if we are to error at all. The following video is an interesting punctuation point.

http://www.examiner.com/video/u-s-finds-first-case-of-mad-cow-disease-six-years

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Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Brazil’s First Case of Mad Cow Disease Hidden for Months

Mad Cow Disease Mismanaged In Brazil

Brazil has notified international animal health regulators of its first case of bovine spongiform encephalopathy, BSE, commonly called mad cow disease. The cow died two years ago, but the test confirming the deadly brain disease was not done until 18 months later, and the results not made public until Thursday.

This time lag allowed Brazil to export roughly 67 million pounds of beef to the United States since the suspect Brazilian cow was identified. Mad cow disease is transmissible to humans who eat beef contaminated with the prions that cause the disease, which is invariably fatal.

mad cow disease

R-CALF USA, a U.S. national, non-profit cattle producers association, warns that this situation points up the need for defending U.S. mandatory country-of-origin labeling now under attack before the World Trade Organization.

“That means the U.S. imported enough beef from Brazil in 2011 and 2012 to feed over one million Americans their annual consumption of beef,” said R-CALF USA CEO Bill Bullard.

“None of that Brazilian beef imported into the U.S. during the past two years was subject to BSE mitigations that are supposed to apply to countries where BSE is known to exist, meaning U.S. consumers have been subjected to an unnecessary and avoidable risk of mad cow disease from Brazil,” said Bullard.

A Brazilian notification submitted Thursday to the World Organization for Animal Health, OIE, identifies a 13-year-old cow that died in December 2010 in Parana state as a suspect for bovine spongiform encephalopathy, BSE, or mad cow disease.

Read More> http://ens-newswire.com/2012/12/07/brazils-first-case-of-mad-cow-disease-hidden-for-months/

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Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

The Genesis of A Prion

Prions Are Deadly Proteins

Infectious prions have a trusty accomplice in causing deadly neurological disease, according to research by Geisel biochemist Surachai Supattapone, M.D., Ph.D. Normal, noninfectious prion proteins are usually found in the brain. But when prion proteins misfold, they can become infectious and trigger a number of fatal brain disorders, such as mad cow disease or Creutzfeldt-Jakob disease in humans.

TSEs are caused by a deadly protein called a prion (PREE-on). As such, TSEs also are referred to as prion disease. The critical factor is that prions are unstoppable. The pathogen spreads through the bodily fluids and cell tissue of its victims. All tissue is infectious just because of the contact with the contaminated blood.

TSEs also include Creutzfeldt-Jakob disease, Parkinson’s, Huntington’s, mad cow disease and chronic wasting disease in the deer family. Few, if any, mammals are immune. There is no cure.

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing deadly prions and prion disease. President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. According to Prusiner, TSEs all are on the same disease spectrum, which is more accurately described as prion disease. He claims that all TSEs are caused by prions.

Prions and Prusiner win Nobel Prize

What puzzles scientists is that infectious prions (simply called “prions”), unlike viruses, have no nucleic acids—no DNA or RNA—yet they are able to create distinct, self-propagating strains of prion diseases. Most scientists believe in a protein-only hypothesis in which prions create different strains of disease on their own, and many believe that the hypothesis may apply to other diseases as well, such as Alzheimer’s disease and Parkinson’s disease.

But Supattapone is doubtful. If a prion contains just a single protein, without other essential molecules, “it’s hard to explain why the strains exist first of all,” he says. Another problem with the protein-only hypothesis, he adds, is that “nobody has been able to make infectious prions from just the prion.”

Through a purification process, Supattapone, with Geisel biochemist Nathan Deleault, determined that when a noninfectious prion protein is mixed with a certain phospholipid molecule, named phosphatidylethanolamine (PE), the combination creates an infectious prion. This experiment was the first time anyone had formed infectious prions from only two components (prion protein and PE) and without any nucleic acids.

Read More> http://dartmed.dartmouth.edu/fall12/html/disc_prion/

Britain Doubles Estimate Of People Carrying Prion Pathogen

Mad Cow Disease A Symptom Of Bigger Problems

About 24,000 people in the UK are carrying the agent that can cause the deadly brain condition Creutzfeldt Jakob disease (CJD), linked with eating infected meat – twice the number previously estimated by scientists. The latest figure is based on a study of 30,000 appendixes removed in operations which were tested for the presence of the prion, or misfolded protein, that causes the condition.

mad cow disease and prions

More than a decade ago ministers assured the public that beef was safe to eat, and then had to eat their words when, in March 1996, it was announced that a new disease, variant CJD, had been discovered in humans.

It had come from eating meat from cows infected with bovine spongiform encephalopathy (BSE), a similar disease caused by the now discontinued practice of feeding ground-up animal carcasses to cows as part of their diet. BSE became known as mad cow disease, and in humans CJD is characterized by rapidly progressive dementia and death.

However, only a small proportion of people who carried the prion developed the clinical disease. There have been 173 cases of variant CJD in the UK since it was first identified in 1996.

prion disease epidemic

The number of carriers of the prion is significant because there is a theoretical risk they could spread the disease through blood transfusions or surgical instruments which are not properly sterilized between operations.

Tough measures are in place to minimize these risks. The Health Protection Agency, which published the new figures, said one in 2,000 of the adult population of Britain were carriers of the condition, compared with one in 4,000 shown in a smaller survey in 2004.

Older people, born before 1961, were twice as likely to be carriers as younger people, yet less likely to develop the disease. Professor Sheila Bird of the Medical Research Council Biostatistics unit in Cambridge said: “Our dietary studies suggested older people were more exposed [to BSE infected meat] but they weren’t turning up as clinical cases. They appear to be protected in some way. This shows how important it is to do the surveillance.”

Professor Hugh Perry, chair of the MRC’s neuroscience and mental health board, said: “These figures reinforce the importance that our efforts to prevent, diagnose and treat this devastating disease progress as rigorously as possible.”

A Department of Health spokesman said: “These findings relate to people’s potential to develop vCJD, not additional cases – in fact there have been no new UK cases for nearly two years.

“We have one of the safest blood supplies in the world, but experts will consider the Health Protection Agency study, and any additional measures to reduce the potential risk of transmission through blood transfusions will be put into place.”

The spokesman denied that a delay in publication of the findings was an attempt to bury bad news during the Olympics. “This was a technical study and part of the regular Health Protection Report that is always released on a Friday afternoon,” he said.

“There is now real evidence of the potential transmissibility of Alzheimer’s disease,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

http://www.independent.co.uk/life-style/health-and-families/health-news/up-to-one-in-2000-britons-could-carry-cjd-agent-8031920.html

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Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Copper Promotes Prion Disease

Copper Not The Causative Agent

Many of us are familiar with prion disease as mad cow disease (bovine spongiform encephalopathy) that created a crisis in the global beef industry. Or the strange story of Kuru, a fatal illness affecting a tribe in Papua New Guinea known for cannibalism. Both are forms of prion disease, caused by the abnormal folding of a protein and resulting in progressive neurodegeneration and death. Today, the human form of prion disease is called Creutzfeldt Jakobs Disease (CJD). Even Alzheimer’s disease is now widely considered a prion disease.

While exactly how the protein malfunctions has been shrouded in mystery, scientists at The Scripps Research Institute now report in the journal Proceedings of the National Academy of Sciences (PNAS) that reducing copper in the body delays the onset of disease. Mice lacking a copper-transport gene lived significantly longer when infected with a prion disease than did normal mice.

“This conclusively shows that copper plays a role in the misfolding of the protein, but is not essential to that misfolding,” said Scripps Research Professor Michael Oldstone, who led the new study.

prion disease epidemic

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing deadly prions and prion disease. President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. According to Prusiner, TSEs all are on the same disease spectrum, which is more accurately described as prion disease. He claims that all TSEs are caused by prions.

Prions are unstoppable and the pathogen spreads through the bodily fluids and cell tissue of its victims. Prions shed from humans are the most deadly mutation. They demand more respect than radiation. Infected surgical instruments, for example, are impossible to sterilize and hospitals throw them away. Prions are in the blood, saliva, urine, feces, mucus, and bodily tissue of its victims.

Many factors are contributing to the epidemic. Prions are now the X factor. Industry and government are not accounting for them or regulating them. They are ignoring the threat completely, which violates the Bioterrorism Preparedness and Response Act of 2002 in the United States. Other nations also are ignoring laws developed to protect food, air and water.

Alzheimer's disease epidemic

“There is now real evidence of the potential transmissibility of Alzheimer’s disease,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

A new study published in the journal Nature renews concern about the transmissibility of Alzheimer’s disease between people. A second study by the same scientist in early 2016 adds to the stack of evidence.

http://www.healthcanal.com/brain-nerves/31489-Scripps-Research-Institute-Scientists-Show-Copper-Facilitates-Prion-Disease.html

public relations firm and public affairs firm Denver and Phoenix

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Florida Woman Dies Of Creutzfeldt-Jakob Disease

CJD Takes Florida Woman

Charlie Bryant is choosing to remember his mother how he saw her most of his life. “She was just the most incredible, charismatic woman,” Bryant said. At 58-years-old, Stephanie Bryant was diagnosed with Creutzfeldt-Jakob Disease (CJD), also known as the human form of mad cow disease–a prion disease. Within months, Stephanie’s health quickly deteriorated. She suffered from memory loss, constant tremors, couldn’t walk and barely talk. Stephanie Bryant passed away Wednesday, Aug. 1.

“It’s the sickest, meanest disease,” Charlie Bryant said.

Prions are unstoppable and the pathogen spreads through the bodily fluids and cell tissue of its victims. Prions shed from humans are the most deadly mutation. They demand more respect than radiation. Infected surgical instruments, for example, are impossible to sterilize and hospitals throw them away. Prions are in the blood, saliva, urine, feces, mucus, and bodily tissue of its victims.

Many factors are contributing to the epidemic. Prions are now the X factor. Industry and government are not accounting for them or regulating them. They are ignoring the threat completely, which violates the Bioterrorism Preparedness and Response Act of 2002 in the United States. Other nations also are ignoring laws developed to protect food, air and water.

prion disease epidemic

“There is now real evidence of the potential transmissibility of Alzheimer’s disease,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

A new study published in the journal Nature renews concern about the transmissibility of Alzheimer’s disease between people. A second study by the same scientist in early 2016 adds to the stack of evidence.

http://www.abc-7.com/story/19198888/woman-with-mad-cow-disease-passes-away

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Creutzfeldt-Jakob Disease In Greenville Hospital System

CJD Exposure In U.S. Hospital

Eleven people who underwent brain surgery at a South Carolina hospital earlier this year  may have been exposed to a deadly neurodegenerative disorder called Creutzfeldt-Jakob disease (CJD).

Prions and Prusiner win Nobel Prize

Reuters reported that a brain surgery patient in February at Greenville Hospital System was later found to have the extremely fatal brain disease. However, before this discovery was made, the same surgical tools were used on 11 other brain surgery patients, though the tools had been sterilized. Unfortunately, protocol typically calls for disposal, not reuse, of all surgical tools used on patients with prion disease.

Prions are unstoppable and the pathogen spreads through the bodily fluids and cell tissue of its victims. Prions shed from humans are the most deadly mutation. They demand more respect than radiation. Infected surgical instruments, for example, are impossible to sterilize and hospitals throw them away. Prions are in the blood, saliva, urine, feces, mucus, and bodily tissue of its victims. Many factors are contributing to the epidemic. Prions are now the X factor. Industry and government are not accounting for them or regulating them. They are ignoring the threat completely, which violates the Bioterrorism Preparedness and Response Act of 2002 in the United States. Other nations also are ignoring laws developed to protect food, air and water.

“There is now real evidence of the potential transmissibility of Alzheimer’s disease,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

A new study published in the journal Nature renews concern about the transmissibility of Alzheimer’s disease between people. A second study by the same scientist in early 2016 adds to the stack of evidence.

Prion disease is always fatal–there is not a known cure and there is not a known way to neutralize them 100 percent. As such, prions are known to migrate, mutate, multiply and kill people, livestock and wildlife.

http://www.huffingtonpost.com/2012/07/31/creutzfeldt-jakob-disease-exposure-greenville-hospital-system_n_1725942.html

public relations firm and public affairs firm Denver and Phoenix

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Pandora’s Lunchbox Filled With Prion Disease

Mad Cow Disease, Chronic Wasting Disease Symptoms Of Bigger Threat To Humans

In my opinion: The recent case of mad cow disease in California once again has people around the world asking questions about food safety. A constructive analysis requires a broader perspective and a refined focus on the causes of all prion diseases.

Contrary to government statements, there is not an isolated case of mad cow disease or any prion disease. Prion disease contributes to deadly forms of environmental contamination that essentially recycle and redistribute the disease. Victims are infectious long before they exhibit clinical symptoms. Chronic wasting disease in various deer species is an explosive example. As prion disease is recycled in the environment and up the food chain, prions mutate and become even more lethal to people and other mammals.

land application sewage sludge

Prion Disease

Mad cow disease, also known as bovine spongiform encephalopathy (BSE), is one of many deadly prion diseases (technically referred to as Transmissible Spongiform Encephalopathy (TSE). TSEs are a spectrum disease, where CJD is the most extreme form. We know prion disease as:

  • Mad-cow disease (in cattle);
  • Creutzfeldt-Jakob disease (CJD, Parkinson’s disease, Huntington’s; disease and Alzheimer’s disease in humans);
  • Chronic wasting disease (CWD in wildlife such as deer, elk, moose and reindeer); and
  • Scrapie (sheep).

The common denominator in all of these diseases is the prion (PREE-on) In addition, according to neuroscientist Laura Manuelidas, about 10-25 percent of Alzheimer’s disease cases are misdiagnosed—they are actually cases of CJD, which is further p the prion spectrum.

Alzheimer's disease epidemic

Furthermore, according to Dr. Claudio Soto at the University of Texas, Alzheimer’s is a prion disease. When you sift through the smokescreen and lump all of these diseases together, it begs the question “do we have a deadly epidemic on our hands and is it being mismanaged.”

Prions are a form of protein that cannot be effectively stopped. They can’t be killed because they are not a virus or bacteria and they don’t contain DNA or RNA. These pathological proteins mutate, migrate, multiply, and intensify. Prion diseases kill everything in their path. In reality, there is no way to contain the disease. There is no cure—prion disease is always fatal. (Studies contend that any prion inactivation procedures must be validated by bioassay against the prion strain for which they are intended to be used.)

Prions are a lethal threat to our food and water supplies. We also risk exposure and infection at hospitals, dental offices, restaurants, and through pet food. The buildup of prions in the environment will get worse with time. Mismanagement is accelerating the process. Various forms of prion disease are already spreading around the world, building up in soil and water, and building up in the bodies of virtually every living creature on the planet. The incubation period and the onset of clinical signs of the disease usually take years, which makes these diseases easier to ignore and more difficult to study.

Prions and Prusiner win Nobel Prize

Prions Earn The Nobel Prize

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and studying deadly prions. President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the growing significance of his discovery. Although his research is ongoing, we know enough about prions to sound the alarm on many levels.

Prions are such a formidable threat that the U.S. government enacted the Bioterrorism Preparedness and Response Act of 2002, which included a provision to halt research on infectious prions in all but two laboratories. Now, infectious prions are classified as select agents that require special security clearance for lab research.

biosolids land application and disease

Thanks to Dr. Prusiner’s discovery and pioneering research, prion disease has been found in humans, livestock and a variety of wildlife species in several countries, including Austria, Canada, Czech Republic, Finland, Germany, Greece, Israel, Italy, Japan, Poland, Slovakia, Slovenia, Spain, United Kingdom, and the United States.

Not only are prion diseases a symptom of a much bigger problem, they are contributing to the buildup of prions in the environment.  A person or animal with prion disease is contaminating their immediate environment and exposing nearby humans and animals to deadly prions.

chronic wasting disease

The Prion Threat to Public Health

The prion pathogen spreads through urine, feces, saliva, blood, milk, soil, and the tissue of infected animals and humans—including bone and muscle tissue. (Contrary to industry reports and a controversial statement from the World Health Organization, research suggests that milk is a pathway to prion exposure).

Humans with Creutzfeldt-Jakob disease (CJD) also are shedding infectious prions into toilets, public sewers and elsewhere. If a single person with prion disease discharges bodily fluids or feces into a public sewer system, that sewage system is permanently infected and the amount of contamination will multiply and intensify over time. The more infected people use the sewage system, the worse the contamination problem. Everything discharged from that sewage system—reclaimed water or biosolids—is at risk of spreading the contamination even further.

Alzheimer's disease prevention

Between 2 and 25 percent of the 4.5 million cases of Alzheimer’s disease and senile dementia victims in the U.S. alone are actually infected with CJD, creating the reality that many thousands of CJD victims are shedding infectious prions throughout their home and everywhere they visit, (Manuelidis, et al, 1989; Boller, et al, 1989, 1995; Harrison, 1991; Teixeira, 1995; Warren, et al, 2005).

Similar pathways exist from an infected cow, sheep, or deer. When infected animals use fields and feedlots, their urine, feces, saliva, and blood permanently contaminates those areas. That contamination becomes bio-available to every creature that follows the path of the infected animal. Those areas are then subject to rainwater and runoff, which can carry the prions further.

sewage treatment plant and disease

Prions No Longer Regulated

In Canada, out of 55,415 cows tested for BSE in 2006, five head of cattle were identified with BSE. If the U.S. only tests 40,000 head of cattle and detects one animal with BSE out of that small test group, we must assume that hundreds more infected animals are missed out of the millions of cattle that are milked and slaughtered each year. Based on those statistics, without comprehensive testing globally, we must assume that beef and dairy operations are producing hundreds of sick animals each year that are being milked, slaughtered and consumed by humans, pets, fish farms, and even other forms of livestock and poultry.

In addition, the land at the feedlot or dairy is contaminated with manure and urine that often is scraped out and used as compost and fertilizer on farms and gardens, which expands the pathways for deadly prions to reach unsuspecting families. “Prions can survive for years in soil,” (Brown, et al 1991). “Animals can become infected from prions in soil,” (Miller, et al 2004). Naturally occurring BSE prions can be up to 1 million times more difficult to inactivate than the most commonly used hamster prions (engineered for clinical studies).

Furthermore, prions can wash from the soil and migrate through irrigation and surface water runoff and settle in groundwater, streams, ponds, lakes, and oceans—where they proceed to multiply and mutate into even more abundant and lethal forms. Wildlife, livestock and humans (especially children) can ingest prions from soil exposure, water exposure, or food. We can’t afford to take the risk of further contaminating entire watersheds – increasing the pathway to humans, livestock, and wildlife downstream.

With these characteristics, there is not an isolated case of Mad-cow or any prion disease. The California dairy where the recent infected animal lived and produced milk is contaminated (two dairies have been quarantined since the discovery of that case of BSE). If the infected cow provided milk to a processor, that supply chain is now in question and those supply chains should be quarantined. In fact, all exposed milk should have been immediately recalled from that entire supply chain. The pathways of that milk still should be traced and condemned.

If the infected animal was rendered for pet food, that rendering plant is now permanently contaminated and will contaminate everything that is processed from now on—exposing our pets to the deadly disease and creating a new pathway in our homes—food bowls that also are permanently contaminated (in fact, an undisclosed rendering plant has been quarantined).

If cattle with BSE are actually processed at a slaughterhouse, that slaughterhouse also is permanently contaminated and will contaminate every carcass that follows the infected animal down the production line. Compounding the problem is the fact that liquid wastes from slaughterhouses are rinsed down the drainpipe and into the municipal sewage system, where they add to the risks associated with that waste stream.

Prion Pathways

Milk and Meat: As stated earlier, highly infectious risk-material (brain and spine) is not the only pathway to prion exposure. Prions have been found in muscle tissue and milk.

Lessons From The United Kingdom: Initially, UK officials insisted the Mad-cow epidemic was not a risk to humans. After 150 human vCJD deaths, they admitted that they were wrong.

mad cow disease and prions

“Thousands of pages of grisly detail on meat-pie making and animal-feed milling might seem like a hard read. As bureaucrats digest the final report of Britain’s BSE inquiry, handed to ministers on October 2nd, 2000 stomachs at the Ministry of Agriculture, Fisheries and Food (MAFF) and the Department of Health must be churning. Not at the finer points of carcass-rendering, but at what is expected to be a thorough dissection of bureaucratic incompetence. Ministers will be considering the findings until the report is presented to Parliament on October 23rd. Three days later, the public will at last be allowed to read the report into Britain’s biggest public-health scandal for decades.

The independent inquiry was established by the UK government to work out the history of two epidemiological crises, bovine spongiform encephalopathy (Mad-cow disease) and its human relative, new-variant Creutzfeldt-Jakob disease (vCJD). The inquiry’s three-person committee, headed by Lord Phillips, a high-court judge, was also asked to assess whether government and industry responded adequately to the situation as it evolved.

Roughly £27m ($39.4m) and 630 witnesses later, the Phillips report is widely expected to be the definitive word on what went wrong in Britain between the first documented cases of BSE in 1986 and the announcement in Parliament, ten years later, that the strange neurodegenerative condition appearing in a handful of young people, now called vCJD, was probably linked to Mad-cow disease.” – The Economist, October 5, 2000.

The Full report from the UK’s BSE Inquiry is available. Furthermore, almost 4,000 Britons aged between 10 and 30 may be harboring the prion proteins that cause the human form of Mad-cow disease. The new estimate comes from direct analyses of human biopsies (tonsils), and is much higher than epidemiological projections of the likely number of deaths from variant Creutzfeldt-Jakob disease (vCJD).

For years, industry experts and government regulators insisted infectious prions could not be found in blood or muscle except for infected sheep and goats. Prions have since been found in blood and muscle of human vCJD and sCJD victims and in the leg muscle tissue of infected deer.

Even organic supplies are not immune from the prion problem. For example, if an organic farm is downstream from a traditional farm that has an animal with BSE, the water runoff from that farm will expose the organic operation downstream to deadly prions.

Let’s assume that everything that the beef and dairy industries, and the USDA, have said about the latest example of Mad-cow disease is true. The tested animal was sent to a rendering plant and was never destined for the food supply.

  1. How much milk did that dairy cow produce before it exhibited clinical signs of the deadly disease? Where did that milk go? On what date was this sick dairy cow withdrawn from the production line? We know that animals are contagious, and shed prions via bodily fluids, including milk, long before they exhibit clinical signs of the disease.
  2. How many other dairy cows have this fatal and contagious disease, but don’t exhibit the clinical signs, yet? How much milk are these animals producing every day?

Growth Hormones and Blood Transfusions: Most growth hormones are made from the pituitary brain of dead cattle or cloned from the DNA of that pituitary gland (bad idea). One infected gland in the production facility and all future products are permanently contaminated. Dairy and beef producers could be injecting BSE directly into live animals with this practice. Similar practices (taking the pituitary gland from cadavers) have killed people from prion disease, including this very recent case from May 2012.

It’s time to stop using growth hormones in beef and dairy cattle. Even if the hormone itself is free of prion disease, what does a growth hormone do to a prion? Has industry or regulators even conducted studies on this dynamic? People have contracted prion disease from infected hormones, infected blood and infected organ transplants. We must assume that the same risk is present for livestock.

Recent studies of variant Creutzfeldt-Jakob disease (vCJD) indicate that this disease is transmissible by blood. One case of probable transfusion-transmitted vCJD infection has been reported, and one case of subclinical infection has been detected. On February 9, 2006, a third case was announced by the UK Health Protection Agency.

Each of the three patients had received a blood transfusion from a donor who subsequently developed clinical vCJD, which indicates that transfusion caused the infection.

Alzheimer's disease infectious

Surgical and Dental Procedures: We can’t sterilize surgical equipment used on people who have prion disease. Prions are so resistant to sterilization that surgical instruments used on a person with CJD must be disposed because they are permanently contaminated. Hospitals have been sued successfully for exposing subsequent patients to deadly prions. Dental and oral surgery settings have the same challenge, but those industries have ignored those risks for the most part.

 

Risk of Prion Disease Transmission through Bovine-Derived Bone Substitutes

Despite the causal association between variant Creutzfeldt – Jakob disease and bovine spongiform encephalopathy (BSE), bovine origin graft materials are widely used during dental surgical procedures. The aim of this study was to assess the risk of BSE transmission through bovine bone substitutes. Methods: Electronic database of MEDLINE was searched to identify relevant studies regarding our focused questions, presence of BSE prion infectivity in raw bovine bone, BSE prion inactivation by bone substitute manufacturing process, protein contents in anorganic bovine bone substitutes, and validity of current BSE diagnostic methods. Search terms yielded 1,704 titles. After title/abstract screening and duplicates removal, 36 full-text articles were screened for inclusion. Results: A total of 16 studies were included in the final analysis. No eligible studies were identified regarding the efficacy of BSE prion inactivation by the treatments used for anorganic bovine bone manufacturing. BSE infectivity and PrP(Sc), pathological prion, were detected in bovine bone marrow and serum samples.

Prions were detected in Tutoplast® (bovine), Bio-Oss®, and tibia samples treated at the similar condition for Bio-Oss deproteinization. Inconsistent results of different BSE diagnostic tests were not unusual findings (Iwata et al. 2006; Arnold et al. 2007; Murayama et al. 2010), and a study by Balkema-Buschmann and colleagues showed an apparent discrepancy between BSE infectivity and detection of PrP(27-30), the current surrogate marker for prion disease infectivity. Conclusion: This review indicates that bovine-derived graft biomaterials may carry a risk of prion transmission to patients.

Limited efficacy of steam sterilization to inactivate vCJD infectivity.

The transmission of bovine spongiform encephalopathy (BSE) to humans as variant Creutzfeldt-Jakob Disease (vCJD) raised concerns about potential secondary transmissions due to the resistance of the agents causing transmissible spongiform encephalopathies (TSEs), sometimes known as prions, to commonly used methods of sterilization, notably steam sterilization (or autoclaving). It has been suggested that surgical instruments and other medical devices might retain sufficient infected tissue debris after cleaning and steam sterilization to infect patients on whom they are subsequently used.

As noted previously, TSE strains derived from BSE sources appear to be more resistant to steam sterilization and other forms of heat inactivation than other TSE sources.

Pet Food: How many infected animals are sent to a rendering plant, never tested for BSE, and are churned into food for dogs, cats, poultry, fish, and zoo animals? What is the likelihood that we are feeding deadly food to our pets? If and when contaminated, that food dish is another pathway for the prion pathogen to enter our homes and bodies, not to mention the risk to our pets. How often do you actually touch that pet food or the dish? How often do you wash that bowl in your kitchen sink?

farmed fish and prion disease

Aquaculture: Many fish farms use specified risk material—SRM (brain and spinal cords) from slaughterhouses and rendering plants as protein meal. What is the likelihood that infected material from a slaughterhouse or a rendering plant was sent to a fish farm (either in a large lagoon or in the open ocean) and dumped into the water and consumed by farmed fish (and wild fish and mammals such as dolphins and whales). Since every microscopic prion can’t be consumed, how much water are we contaminating every year to extend this science experiment via new pathways.

This questionable practice puts the health of the fish at risk and those who eat the fish. Secondly, the water that the risk material is dumped becomes contaminated with prions, which threatens groundwater, surface water runoff, streams, rivers, and oceans with deadly prions. This factor could be contributing to the deaths of dolphins and whales and it could be contributing to prion disease in people. Many fish have contracted Whirling disease, which could be a form of prion disease (needs research that this author has not conducted, yet).

Animal Rendering & Anaerobic Digestion Of Carcasses: “It’s necessary to use additional heat at the end of the rendering process to fully inactivate pathogens.  However, even with this, prions are not inactivated,” APHIS/USDA, January 2005.

“While finished compost can be spread on farmland as fertilizer, if prions are present and the compost is used as fertilizer prions can re-enter the food chain through grazing plants, hay and straw obtained from those areas. Thus, composting should not be used to dispose of infected deer, elk, sheep, goats, or cattle. Composting is especially unsuitable for specified risk materials, especially neural tissues (skull and spinal cord) encased in bones. The indiscriminate use of composting and spreading its byproducts on agricultural land is inconsistent with the FDA feed rule, would dilute its integrity and invalidate all existing BSE/TSE risk assessment models. This is similar to what may have transpired with the CWD material, given the WIDNR (Wisconsin Department of Natural Resources) disposal policy was indeed implemented,” National Renderers’ Association response to USDA and APHIS, June 2005.

Lotions & Cosmetics

How safe is collagen material? Our purified collagen material is extremely safe and is being used in the manufacture of finished medical devices currently on the market. All collagen devices manufactured by Collagen Matrix, Inc. have passed biocompatibility testing in accordance with ISO 10993 Biological Evaluation of Medical Devices. Any additional potential concerns such as viruses, BSE, bacteria, and pyrogens have been addressed thoroughly in manufacturing process control which includes a step that is proven to inactivate BSE, quality control testing, validations, and internal risk analyses.

Is Mad Cow Disease or Bovine Spongiform Encephalopathy (BSE) transmission a concern with the use of your collagen?

The risk of transmitting Mad Cow Disease, Bovine Spongiform Encephalopathy (BSE) or viruses through the use of bovine tendon or corium as a raw material source of type I collagen for medical devices is considered negligible. This conclusion is based on a thorough investigation and risk analysis process in which various aspects of the material from animal sourcing and harvesting to finished product testing were evaluated. There has been no such documented case of BSE transmission through a medical device using bovine-derived collagen material.

Cosmetic Ingredients, Risks

From cosmetics, candy and gelatins to drugs for diabetes, hay fever and arthritis, there are beef parts in dozens of products that people use every day. Worries about the safety of British beef spread beyond just steaks and chops Wednesday when the European Community ordered Britain to stop exporting all beef-derived products including ice cream, candy, cosmetics and drugs.

U.S. scientists noted, however, that very few of these products use pieces of the steer’s brain and spinal cord, the only parts of the steer’s body where mad cow disease, or bovine spongiform encepthalopathy, has been found. The most widely used beef product is collagen, the spongy substance derived from beef skin or bones. Collagen is often an ingredient in ice cream, custards, cheeses, candies, sausage casings and cosmetics.

Even if it were found to be a carrier, the vast majority of the collagen in U.S. products comes from domestic beef because it is so plentiful, said Bob Rust, professor emeritus in meat science at Iowa State University.

The FDA, prior to approval of any drug with beef products, should require the manufacturer to certify that the beef only come from countries free of the disease. It does not. The variety of drugs derived from cattle parts is diverse and includes:

  • Growth hormones come from the cattle pituitary glands.
  • Adrenalin products for hay fever, asthma and other allergies, from the adrenal gland.
  • Cortizone, for arthritis, asthma, shock, also from the adrenal gland.
  • Insulin, for diabetics, from the pancreas.
  • Tissues used as patches during heart bypass surgery, from the bovine pericardial tissue.
  • Thromboplastin, a blood coagulant used in surgery, from the brain.
  • Drugs for the treatment of stomach ulcers.
  • Gelatine capsules for many drugs are made from cattle tissues.

biosolids land application LASS

Sewage Sludge, Biosolids, Wastewater Reuse

In June 2012, Nobel Laureate Stanley Prusiner, UCSF, confirmed that Alzheimer’s Disease (AD) is a prion disease like CJD and mad cow. AD victims shed infectious prions in their blood, saliva, mucous, urine and feces. The infectious prions bind to the sewage sludge, including sludge/biosolids/compost, being applied on home gardens, US cropland, grazing fields and dairy pastures, putting humans, family pets, wildlife and livestock at risk.

Other prion contaminated wastes discharged to sewers include rendering plants (which process remains of 2 million potentially BSE infected downer cows each year), slaughterhouses, embalmers and morticians, biocremation, taxidermists, butcher shops, veterinary and necropsy labs, hospitals, landfill leachates (where CWD infected and other carcasses are disposed), Drinking water is at risk for prions if it comes from a surface source (river or lake) which receives treated sewage effluent. Chlorination does not inactivate prions.

The US EPA lists prions as a contaminant of concern in sludge and water eight times.

Renown prion researcher, Dr. Joel Pedersen, University of Wisconsin, found that prions become 680 times more infective in certain soils.

Dr. Pedersen’s research also proved sewage treatment does not inactivate prions: “Our results suggest that if prions were to enter municipal wastewater treatment systems, most of the agent would partition to activated sludge solids, survive mesophilic anaerobic digestion, and be present in treated biosolids. Land application of biosolids containing prions could represent a route for their unintentional introduction into the environment. Our results argue for excluding inputs of prions to municipal wastewater treatment.”

“Prions could end up in wastewater treatment plants via slaughterhouse drains, hunted game cleaned in a sink, or humans with vCJD shedding prions in their urine or feces,” Pedersen says.

In the July 3, 2010 issue of VETERINARY RECORD, Dr. Pedersen stated: “Finally, the disposal of sewage sludge was considered to represent the greatest risk of spreading (prion) infectivity to other premises.”

It is well known that sewage sludge pathogens, pharma and chemical pollutants are taken up by plants and vegetables. The Canadian Food Inspection Agency recently warned that plants can uptake infectious prions: “. . . there is a potential risk to humans via direct ingestion of the compost or of compost particles adhered to skin or plant material (e.g. carrots). Another potential route of exposure is by ingestion of prions that have been taken up by plants.”

Thousands of tons of sewage sludge (biosolids) are spread on farmland, parks, open spaces, and even lawns and gardens every year. In addition, millions of gallons of sewage water are being reclaimed for various uses.  Spreading sewage sludge and reclaimed sewage water on fields and in our watersheds is another foolish and risky practice. People with CJD (and many with Alzheimer’s disease) excrete prions in their urine, feces, saliva and blood and these recycling practices also are recycling, concentrating and expanding pathological pathways back to humans.

“Prions have been found in the blood and urine of CJD victims,” Gabizon, et al, 2001; Reichl, et al 2002. “Undertakers and medical facilities routinely discharge CJD infected blood and body fluids into public sewers,” Yale, UC Davis, Center for Disease Control.

Prions are not neutralized by sewage treatment. Therefore, prions become part of the sewage sludge and create pathways to the disease on fields and water runoff. It’s time to quit spreading lies and pathogens on farmland and pastures where livestock graze and where surface water runs off into streams, rivers, lakes and ponds.

Sewage treatment does not inactivate prions. In fact, it concentrates the infectious prions in the sewage sludge being applied on home gardens, cropland, grazing fields and dairy pastures, putting humans, family pets, wildlife and livestock at risk.

“Prions are extremely resistant to inactivation by ultraviolet light, irradiation, boiling, dry heat, formaline, freezing, drying and changes in pH. Methods for inactivating prions in infected tissues or wastes include incineration at very high temperatures and alkaline hydrolysis,” U.S. EPA.

Oral transmission of prion disease is enhanced by binding to soil particles. Dr. Pedersen and associates found that anaerobic digestion sewage treatment did not inactivate prions in sludge. Persistence of pathogenic prion protein during simulated wastewater treatment processes.

“Given it is unlikely that the sewage treatment or pellet production processes can effectively deactivate prions, adopting measures to prevent the entry of prions into the sewer system is advisable,” Toronto (Canada) Department of Health, Nov. 2004.

“Pathogen free” is clearly not the case when the Class A sludge compost can contain infectious human and animal prions. Not only are livestock and wildlife at risk from ingesting prion infected soil and sludge, but humans, and particularly children, are especially at risk because their hand to mouth behavior results in the ingestion of dirt,
(Robischon, 1971; LaGoy, 1987; Binder, et al 1986; Gerba, et al 2002; CDC, Callahan, 2004).

Given the volumes of research that clearly point to the risks associated with sewage sludge, how many cattle are being exposed to prions by grazing on land where sewage sludge (biosolids) has been applied? This exposure alone could spawn countless cases of Mad-cow disease around the globe every year. In addition, how many humans have ingested prions directly thanks to this foolish practice? How much water has been contaminated thanks to sewage sludge applications in our watersheds and directly injected into our rivers and oceans?

Sludge proponents claim that there aren’t enough prions in sludge to constitute an infectious dose.This statement shows incompetency or a reckless disregard for human and environmental health. Prions are known to multiply, which means that one can become thousands or millions once a facility or property is contaminated with even the smallest particle.

“Critics say that one example of outdated assumptions is the Harvard study’s assumption that a cow would have to eat one gram of infected material to come down with the disease. Most scientists now believe a cow would have to eat only 10 milligrams of infected material, a piece the size of a peppercorn, to catch the disease. That’s 100 times smaller than the assumption in the Harvard study. Recent British studies suggest the infectious dose could be 400 micrograms, which is 25 times smaller than 10 milligrams,” said Dr. Michael Hansen.

*Above Sources on Sewage Risks Compliments of Helane Shields/

Additional Documents & Research of Interest

“BSE has now been transmitted orally to 16 species,” (S. Dealler, 1995). Animals which have suffered fatal prion diseases include sheep, goats, cattle, pigs, bison, elk, mule and white-tailed deer, oxen, moose, domestic house cats, several species of macaques/monkeys, several species of lemurs, farmed mink, cougars, cheetahs, puma, ocelot, tiger, lion, kudu, oryx, eland, nyala, gemsbok and ankole.Rendered sheep fed to cattle are believed to have initiated the Mad-cow epidemic. Intensive inbreeding of sheep for various genetic characteristics is thought to have spawned prion disease in sheep.

 Contaminated meat and MBM feed are linked to zoo animal infections. A 1999 report documented three German zoo ostriches, which developed prion disease after eating feed made from downer cattle. An elephant at the Oakland Zoo died of prion disease.

Under ordinary circumstances, most sCJD cases go undiagnosed. Few autopsies are done on suspected sCJD victims because the families don’t want to incur the expense. What’s the point if their loved one is already dead? And the pathologist/medical examiner is reluctant to do an autopsy because he/she is concerned about their own risk of infection and the fact that expensive medical instruments may have to be discarded if the case is positive.

By binding to a common soil mineral, the misshapen proteins that cause chronic wasting disease in deer can be as much as 700 times more infectious than exposure to the proteins alone, according to researchers at UW-Madison. The finding, by UW-Madison animal health and biomedical science professor Judd Aiken, may help explain why CWD spreads orally among Wisconsin deer even though animals in the wild are exposed to relatively low levels of the infectious proteins, called prions. Herbivores, including deer and sheep, consume a fair amount of dirt each day as they graze. They also are known to consume soil as a source of minerals. Grazing cattle are known to ingest one kilogram of soil per day (2.2 pounds)

Creutzfeldt-Jakob disease contamination

Health Risk Summary

There are many prion pathways that we need to address and this paper has just scratched the surface in an attempt to redirect the conversation about Mad-cow disease to more productive ground. We still have much to learn about prions and we can’t afford to compartmentalize our thinking based on one pathway or the species affected—prion disease is prion disease, regardless of whether it is killing an animal or a human, or whether the deadly prion is being discharged by an animal or a human. The idea of species barriers for the most part is a myth. However, some races and species appear to be more susceptible (ask the Koreans and Japanese about their research, which points to a higher susceptibility in their genetic makeup). These countries are very quick to test beef and ban beef from any countries of origin with unacceptable risks.

If prions must be tightly regulated in a laboratory environment today, the outdoor environment and other pathways should be managed accordingly. If we can’t sterilize surgical equipment used on people who have prion disease, why are we kidding ourselves that we can neutralize prions in sewage? Dilution is not a solution to prion contamination. Prions don’t have a half-life as radiation does. They multiply, which means even one will become many. They can’t be stopped and the diseases always are deadly.

It’s time to develop a comprehensive prion-management strategy that maximizes safeguards for human health, food, water, and wildlife around the globe.  We have to stop the practice of using biosolids and reclaiming sewage water. We need to rethink several other health care and food-safety practices, too.

The stakes are too high for fragmented and misguided prion policies. It’s time to stop spreading pathogens, misinformation and lies.

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Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Brain Disease Recycled Through Sewage Sludge

Biosolids Spreading Brain Disease

Colm Kelleher, the author of Brain Trust: The Hidden Connection Between Mad Cow Disease and Alzheimer’s Disease is a fascinating book that covers al lot of ground quickly. It connects many dots about deadly prion diseases.

One pathway that he doesn’t mention is sewage sludge, which exposes livestock, wildlife and humans to the largest prion pathway in the world. Beef and dairy cattle are raised on land contaminated with infectious waste. The infectious prions also contaminate water supplies from that point to downstream reservoirs, including creeks, ponds, rivers, lakes and oceans.

land application sewage sludge

If you study the rates of AD and its geographical distribution, you will find that rates start to soar when a country becomes meat eating (i.e. Japan and Korea in the 1960s) and rises even faster when it adopts a fast food culture (the US and Western Europe in the 50s and 60s) and remains low in vegetarian countries (India) and those without a processed meat industry or fast foods (equatorial Africa)…Murray “

 

Rendering plants, which yearly process over 1 million downer cows  – the ones most likely
to have with prion disease –  can result in infected feeds. Industrial meat packing vats of hamburger, each containing meat from 50 to 100 animals from multiple states and two to four countries may also promote contamination and infection.

In order to understand the threat, one must understand the dynamics of this neurological disease. Alzheimer’s disease, for example, is a member of an aggressive family of neurodegenerative diseases known as Transmissible Spongiform Encephalopathy (TSE). The operative word is “transmissible.”

TSEs are caused by a deadly protein called a prion (PREE-on). As such, TSEs also are referred to as prion disease. The critical factor is that prions are unstoppable. The pathogen spreads through the bodily fluids and cell tissue of its victims. Blood, saliva, mucus, milk, urine and feces carry deadly prions from victims. All tissue is infectious just because of the contact with the contaminated blood.

TSEs also include Creutzfeldt-Jakob disease, Parkinson’s, Huntington’s, mad cow disease and chronic wasting disease in the deer family. Few, if any, mammals are immune. There is no cure.

prion disease epidemic

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing deadly prions and prion disease. President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. According to Prusiner, TSEs all are on the same disease spectrum, which is more accurately described as prion disease. He claims that all TSEs are caused by prions.

Prions are unstoppable and the pathogen spreads through the bodily fluids and cell tissue of its victims. Prions shed from humans are the most deadly mutation. They demand more respect than radiation. Infected surgical instruments, for example, are impossible to sterilize and hospitals throw them away. Prions are in the blood, saliva, urine, feces, mucus, and bodily tissue of its victims. Many factors are contributing to the epidemic. Prions are now the X factor. Industry and government are not accounting for them or regulating them. They are ignoring the threat completely, which violates the Bioterrorism Preparedness and Response Act of 2002 in the United States. Other nations also are ignoring laws developed to protect food, air and water.

“There is now real evidence of the potential transmissibility of Alzheimer’s disease,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

A new study published in the journal Nature renews concern about the transmissibility of Alzheimer’s disease between people. A second study by the same scientist in early 2016 adds to the stack of evidence.

mad cow disease and prions

It’s highly probable that livestock and wildlife are contracting TSEs from humans via sewage sludge, also known as biosolids. Consuming milk and meat from infected animals brings the disease back into the human food chain. In other words, we’re recycling Alzheimer’s disease and Creutzfeldt-Jakob disease becasue of the mismanagement of infectious waste.

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Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.